Close to Rotunda and Galerius’ Arch (Kamara), you can find the church of Aghios Panteleimon, a spiritual center in the 14th century, a place where the remarkable Hellenists Thomas Magistros and Matheos Vlastaris used to write and teach. Built in the late 13th century as the catholicon of Panagia Perivleptou Monastery, also known as Mr. Isaac’s Monastery named by its founder, Jacob, the bishop of Thessaloniki, thereafter monk Isaac. It belongs to the type of composite cruciform with a dome and ambulatory, while two chapels are formed at the eastern end of the side porticos.